Yes, you can perform mathematical convolution in Excel using the built-in function called "CONVOLVE". Here's how you can do it:

1. First, enter the two sets of data that you want to convolve into two separate columns in your Excel worksheet.
2. Next, select a blank cell where you want the result of the convolution to appear.
3. Type "=CONVOLVE(" into the formula bar, and then select the first range of data that you want to convolve.
4. Type a comma "," and then select the second range of data that you want to convolve.
5. Type a closing parenthesis ")" and press Enter.
6. The result of the convolution will appear in the cell you selected.

Note that the CONVOLVE function in Excel performs a discrete convolution, which means that it assumes that the two sets of data are sampled at regular intervals. If your data is not sampled at regular intervals, you may need to interpolate it before using the CONVOLVE function.