I use the <F2 key constantly to enter the edit mode and sometimes I
accidentally hit the <F1 instead, starting Excel's help feature. Can I make
it stop?

Chip Pearson says that he actually "fixed" his keyboard by taking that key off.
Others say that they left the key, but removed the spring underneath.

But you could use a couple of macros (one to disable and one to enable):

Option Explicit
Sub disableF1()
Application.OnKey "{f1}", ""
End Sub

This would toggle it back to normal.

Sub enableF1()
Application.OnKey "{f1}"
End Sub

If you're new to macros, you may want to read David McRitchie's intro at:
http://www.mvps.org/dmcritchie/excel/getstarted.htm

sonic_d_hog wrote:

I use the <F2 key constantly to enter the edit mode and sometimes I
accidentally hit the <F1 instead, starting Excel's help feature. Can I make
it stop?

--

Dave Peterson