I checked on the forum before posting and tried deleting rows/columns,
didn't work. When I hit Ctrl-End it only goes to O27.

There is hardly anything in this spreadsheet, it is half a page and
has two macro buttons, one to print/email, one to create a new tab.

Since 2006 it was always around 700kb, now it is 5 mb. When you key
in text or a number the hourglass appears and it takes 1-2 seconds.
Saving is no longer than usual.