I have a main worksheet that I have hyperlinked all of the other worksheets.
It would be best if the user can always open this spreadsheet and go to this
main sheet right away.

If you save it with that worksheet selected, then it'll open that way.

Or you could use a macro (in a general module):

option explicit
sub auto_open()
application.goto thisworkbook.worksheets("Sheet99").range("a1"), _
scroll:=true
end sub

If you're new to macros, you may want to read David McRitchie's intro at:
http://www.mvps.org/dmcritchie/excel/getstarted.htm

GT wrote:

I have a main worksheet that I have hyperlinked all of the other worksheets.
It would be best if the user can always open this spreadsheet and go to this
main sheet right away.

--

Dave Peterson