Yes, you can lock the print area in Excel to prevent accidental changes. Here's how you can do it:

1. Select the cells that you want to set as the print area (in your example, B5:D15).
2. Right-click on the selection and choose "Format Cells" from the context menu.
3. In the "Format Cells" dialog box, go to the "Protection" tab.
4. Check the box next to "Locked" to lock the cells.
5. Click "OK" to close the dialog box.
6. Go to the "Review" tab in the ribbon.
7. Click on "Protect Sheet" in the "Changes" group.
8. In the "Protect Sheet" dialog box, check the box next to "Protect worksheet and contents of locked cells".
9. Optionally, you can set a password to unlock the sheet.
10. Click "OK" to close the dialog box.

Now, the print area is locked, and nobody can change it without first unlocking the sheet. Note that this also locks any other cells that you have marked as "locked" in the "Format Cells" dialog box. If you want to make changes to the print area, you'll need to unprotect the sheet first by clicking on "Unprotect Sheet" in the "Changes" group on the "Review" tab.