is it possible to make a lookup_reference and lookup result directly from a
non-adjacent cells,,

maybe something like this...

=LOOKUP(A1,{U1:V1&","&X1:Y1&","&AA1:AB1},{I1:J1&", "&L1:M1&","&O1:P1})

like if the value on A1
is exactly equal to a value on either U1 or V1, then RESULT will be from L1
or M1, and if not found, it will search again on the next...

if not possible, please advice

thanks and more power
driller