Once you've got your answer you can write a macro that will run when the
workbook is saved. Maybe not the most succinct method, but the only one
I know:

In 'ThisWorkbook' write:

Private Sub Workbook_BeforeSave(ByVal SaveAsUI As Boolean, Cancel As
Boolean)
If Cells(y1,6).value = "yes" then
If Cells(y2,5).value = "" then
MsgBox("Please enter value in cell y2,5)
Cancel = True
End If
End If
End Sub

where y1 and y2 are the relevant rows.


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PipTT
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