Duplex Open at top. If that doesn't work printing your spreadsheet
directly to the printer, then try creating PDF file, then Print the PDF
file "Duplex, Open at top".

wrote:

Does anyone know if it's possible to setup an Excel document in Excel
so it prints (or is laid out) from Head to Toe? I have these massive
documents I need to put into books and organize this way. I have
tried finding this functionality in Acrobat, unsuccessfully, so I
thought there might be a way to set this up with the source document
(Excel).

Any help most appreciated!

Thanks,

Stuart