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britt britt is offline
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Default launch from explorer in Vista - multiple instances of Excel

You can edit the registry on Vista and Windows 7 and it does the exact
same thing as changing the file association through XP.

Delete the following lines in the registry:
HKCR\Excel.Sheet.8\shell\Open\ddeexec
HKCR\Excel.Sheet.12\shell\Open\ddeexec
and change the below like shown:
HKEY_CLASSES_ROOT\Excel.Sheet.12\shell\Open\comman d
C:\Program Files\Microsoft Office\Office12\EXCEL.EXE /e “%1″
HKEY_CLASSES_ROOT\Excel.Sheet.8\shell\Open\command
C:\Program Files\Microsoft Office\Office12\EXCEL.EXE /e “%1″