I'd bet you have a macro that steals that shortcut.

If you want to turn it off...

Chip Pearson has some notes on how to diagnose startup errors:
http://www.cpearson.com/excel/StartupErrors.htm

And Jan Karel Pieterse has more notes:
http://www.jkp-ads.com/Articles/StartupProblems.asp

echou wrote:

When I hit ctrl S sheet will sort instead of save

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Dave Peterson