Does it happen on other pc's?

Does it happen when you start excel in safe mode?
close excel
windows start button|Run
excel /safe
file|open yourworkbook
and test it out.

Does it only happen on that pc?

Are you saving locally or to a network drive?

Do you have antivirus software enabled?

There's lots of things that could be sticking their ugly heads in the way. I
think you'll have to do some detective work--and maybe you'll get lucky and find
the culprit.

The-Bee wrote:

I have a very large workbook - over 100 sheets. Each has from 50 to 1200
cells filled. It locks up just about every time I change a cell and try to
save the file. On a good day I can save two changes without locking and
rebooting. As you can imagine this is a real pain - especially since I will
need to make a few thousand changes in the next week.
Any ideas? I am running XP Professional on a Dell with more than adequate
space on my hard drive (still 85% free).
I did all the usual - defrag, scan disk, etc.

--

Dave Peterson