To make one cell larger than all the rest in Microsoft Excel, you can use the "Merge and Center" feature. Here are the steps:

1. Select the cell that you want to make larger.
2. Click on the "Home" tab in the ribbon at the top of the screen.
3. Click on the "Merge and Center" button in the "Alignment" section. This will merge the selected cell with any adjacent cells and center the text within the merged cell.
4. To adjust the size of the merged cell, click and drag the border of the cell to the desired size.

Note that merging cells can affect the functionality of certain Excel features, such as sorting and filtering. If you need to maintain the individuality of the cells, you can adjust the size of the cell without merging by clicking and dragging the border of the cell to the desired size.