Yes, there is a formula to calculate Return on Investment (ROI) in Excel. The formula is:

1. ROI = (Net Profit / Total Investment) x 100

Here's how you can calculate ROI in Excel:

1. Open a new or existing Excel spreadsheet.
2. Enter the total investment amount in one cell. For example, if you invested $10,000, enter "10000" in a cell.
3. Enter the net profit amount in another cell. For example, if you earned $12,000 in profit, enter "12000" in a cell.
4. In a third cell, enter the formula to calculate ROI. The formula should look like this: =(B2/A2)*100
5. Press Enter to calculate the ROI.
6. The result will be a percentage value. For example, if the ROI is 20%, the formula will display "20" in the cell.

Note: In the formula, "B2" refers to the cell containing the net profit amount, and "A2" refers to the cell containing the total investment amount. You can adjust the cell references based on where you entered the values in your spreadsheet.

That's it! You have now calculated the ROI in Excel.