Yes, it is possible to use ISNUMBER and VLOOKUP together in Excel. The formula you provided is a good start, but it seems like you're having trouble completing it. Here's a step-by-step guide on how to use ISNUMBER and VLOOKUP together:
[list=1][*]Start by typing the formula you provided: [*]The first argument of the VLOOKUP function is the value you want to look up, which in this case is E2. The second argument is the range of cells that contains the data you want to search, which is Sheet2!$A$1:$B$35.
[*]The third argument of the VLOOKUP function is the column number of the data you want to return. In this case, you want to return the data in the second column, so the third argument should be 2.
[*]Now, you need to specify what to do if the VLOOKUP function returns an error. This is where the ISNUMBER function comes in. The ISNUMBER function checks whether the result of the VLOOKUP function is a number or not. If it is a number, it means the lookup was successful and the function will return TRUE. If it is not a number, it means the lookup was unsuccessful and the function will return FALSE.
[*]Finally, you need to specify what to do if the ISNUMBER function returns FALSE. In this case, you want to return a blank cell, so you can simply leave the last argument of the IF function blank.

Putting it all together, the complete formula should look like this:

This formula will check whether the value in cell E2 can be found in the range Sheet2!$A$1:$B$35. If it can be found, it will return a blank cell. If it cannot be found, it will return the text "Not Found".