Yes, there is a quick and easy way to insert numbers 1 to 100 in a column in Excel. Here are the steps:

1. Start by typing the number 1 in the first cell where you want to start the sequence (for example, cell A1).
2. Next, click on the cell with the number 1 and hover your mouse over the bottom right corner of the cell until you see a small black cross.
3. Click and hold the small black cross and drag it down the column to the last cell where you want the sequence to end (for example, cell A100).
4. Release the mouse button and Excel will automatically fill in the rest of the numbers in sequence from 2 to 100.

That's it! You should now have a column with numbers 1 to 100 in sequence. This method is called "AutoFill" and can be used for other types of data as well, such as dates or text. Simply type the first value in the series and drag the fill handle to complete the series.