Per your criteria:

Application.Names.Add Name:="Timeline", _
RefersTo:=Range([b4], [b4].End(xlDown).End(xlToRight))

or

Application.Names.Add Name:="RangeName", _
RefersTo:=Range(Range("b4"), Range("b4").End(xlDown).End(xlToRight))


--
MacGuy


"Kori" wrote:

I am trying to write a macro that uses Define Name to name a range of cells.
The range is always changing as rows and columns get added/deleted, so I
tried using 'Selection.End' functionality. However, when it gets to RefersTo
in Define Name, it hard codes the range instead of using the currently
selected range. Any thoughts? Thanks!

Sub Naming()
'
' Naming Macro
'

'
Range("B4").Select
Range(Selection, Selection.End(xlDown)).Select
Range(Selection, Selection.End(xlToRight)).Select
ActiveWorkbook.Names.Add name:="Timeline", RefersToR1C1:= _
"=Timeline!R4C2:R49C66"
ActiveWorkbook.Names("Timeline").Comment = ""
Range("B2").Select
End Sub