We have a VB 6 program that one of the things that it does is open
spreadsheets as Excel.Application's, but a client of ours gets a message that
the files are in use. The files are not in use. All users have rebooted
their machines. This started occurring after they did an upgrade to Office
2003.

Other clients do not have this problem. Is there a setting that could have
been changed during this upgrade?