Yes it is possible

One way

On the module sheet that is for the speadsheet you want to trigger the
macro you need a change event macro

Private Sub Worksheet_Change(ByVal Target As Range)
'add target.address testing if required
If Target.Value < 0 Then
Application.EnableEvents = False
Call MyMacro
Application.EnableEvents = True
End If
End Sub


--
mudraker
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