I have a friend who has paralysis of his right side. All his
keyboarding is one-handed. He would like to use a keyboard shortcut --
say ctrl-z to start recording his key strokes...say down 2 right 4 from
the ActiveCell, edit that cell. Then when he moves to the next cell the
'macro' can be invoked again. When finished the macro needs to
'disappear' to be replace the next time he runs it.

I have found most of what I need, assigning and unassigning the
shortcut keys, and the cell movement and editing is all good. - well
it works, I am after all a VBA hack :-) - but I haven't been able to
find any method that would prompt the user to enter 'anything' and have
those movements recorded other than invoking the macro recorder from
the worksheet.

Is this possible, or am I barking up the wrong tree?

Andy