creating template

I am creating a template to calulate information that is downloaded from
another program. The information is downloaded into different sheets and i
need to do lookups to bring the information into one sheet. The problem i
have is that there are subtotals to be placed on the sheet but the
information is not always in the same format. In one download there may be
four items to calculate while in another download there may be only three.
Is there any programming I can use to calculate the subtotals once all the
items are in place?

Thanks